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Correspondence
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Volume 354:879-880 February 23, 2006 Number 8
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Probenecid with Oseltamivir for Human Influenza A (H5N1) Virus Infection?

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To the Editor: Probenecid is an inexpensive medication that was widely used when penicillin was in short supply. Owing to the current easy access to abundant supplies of penicillin, this approach is primarily of historical interest. In light of the limited supply of oseltamivir, however, it may be time to revisit the use of probenecid as adjunctive therapy for human influenza A (H5N1) virus infection. Coadministration of oseltamivir and probenecid has resulted in a reduction in the clearance of oseltamivir by approximately 50 percent and a corresponding doubling of the plasma levels of oseltamivir.1 Therefore, part of the planning for . . . [Full Text of this Article]



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