FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 354:970-971 March 2, 2006 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

The use of RNA interference (RNAi) as an experimental tool to analyze mammalian gene function has increased dramatically over the past five years. Its application to animal models of human disease is also on the increase. Palliser and colleagues recently provided an example: they used RNAi to prevent herpes simplex virus 2 (HSV-2) infection of the vaginal mucosa of mice,¹ opening up possibilities for the development of topical RNAi microbicides to block viruses as they enter the body.

RNAi was first described in plants and later found to be an endogenous process by which mammalian messenger RNAs (mRNAs) are inactivated.^2,3 . . . [Full Text of this Article]

Source Information

From the Department of Molecular Microbiology and Immunology, Oregon Health and Science University, Portland.

This article has been cited by other articles:

• Lee, H. S., Ahn, J., Jee, Y., Seo, I. S., Jeon, E. J., Jeon, E.-S., Joo, C. H., Kim, Y. K., Lee, H. (2007). Universal and mutation-resistant anti-enteroviral activity: potency of small interfering RNA complementary to the conserved cis-acting replication element within the enterovirus coding region. J. Gen. Virol. 88: 2003-2012 [Abstract] [Full Text]