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Previous Volume 354:972-974 March 2, 2006 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Wang et al. (Dec. 1 issue)¹ report that, as compared with atypical antipsychotic medications, the use of conventional antipsychotic agents increased the death rate among elderly users. Although we appreciate the instrumental-variable analysis, we have two concerns. First, it seems as though confounding would still be possible if the instrumental variable (a physician's choice of a conventional antipsychotic medication as his or her most recent prescription) was independently associated with the outcome (risk of death of the index patient). This confounding could happen if physicians who choose conventional antipsychotic medications also tend to care for very sick . . . [Full Text of this Article]

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