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Volume 354:979-980 March 2, 2006 Number 9
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Cullen's and Turner's Signs

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by Mookadam, F.
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To the Editor: Cullen's and Turner's signs have long been known to be associated with retroperitoneal bleeding, as illustrated in the images presented by Mookadam and Cikes (Sept. 29 issue).1 However, the mechanisms underlying the appearance of these signs have only recently been clarified with a better understanding of the embryonic development of the various layers of the retroperitoneum.2,3 Cullen's sign arises from the spread of retroperitoneal blood into the falciform ligament and subsequently to subcutaneous umbilical tissues through the connective tissue covering of the round ligament. In contrast, Turner's sign is produced by hemorrhagic fluid spreading from the posterior . . . [Full Text of this Article]



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