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Previous Volume 355:89-90 July 6, 2006 Number 1 Next

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In 2003, the field of diabetes was shaken up by an article published in Science,¹ stating that established autoimmune diabetes in mice could be permanently reversed with the injection of spleen cells. Kodama et al. reported that a known immune modulator, complete Freund's adjuvant, and the temporary transplantation of islets to the kidney capsule could be coupled with the injection of splenocytes to cure diabetes in mice. The idea was that the adjuvant modulates the immune attack and the transplanted islets maintain normal blood glucose levels long enough for the spleen cells to regenerate the insulin-producing beta cells. The authors . . . [Full Text of this Article]

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From the Harvard Stem Cell Institute, Department of Molecular and Cellular Biology, Harvard University, Boston.

Related Letters:

Reversal of Type 1 Diabetes in Mice
Faustman D. L.
Extract | Full Text | PDF  
N Engl J Med 2007; 356:311-312, Jan 18, 2007. Correspondence

This article has been cited by other articles:

• Faustman, D. L. (2007). Reversal of Type 1 Diabetes in Mice. NEJM 356: 311-312 [Full Text]