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FOCUS ON RESEARCH Volume 355:973-975 September 7, 2006 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Editorial by Drazen, J. M. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Suntharalingam, G. PubMed Citation

The immune system has the remarkable ability to defend against diverse microbial pathogens and yet not to respond to self. T cells are key mediators of the immune response, and their activation is tightly regulated to prevent autoreactivity. The processes of T-cell activation and self-tolerance are therefore potential targets for manipulation by drugs — hence, the recent phase 1 trial of a "superagonistic" monoclonal anti-CD28 antibody that was conducted in Britain on behalf of the German firm TeGenero, with the unexpected and devastating results described by Suntharalingam et al. in this issue of the Journal (pages 1018–1028).

T-cell activation requires . . . [Full Text of this Article]

Source Information

This article was published at www.nejm.org on August 14, 2006.

Dr. Sharpe is a professor of pathology at Harvard Medical School, Boston. Dr. Abbas is a professor and chair of the Department of Pathology at the University of California, San Francisco, San Francisco.

Related Letters:

T-Cell Costimulation
Wise M. P., Gallimore A., Godkin A., Colaco C. A.L.S., Sharpe A., Abbas A.
Extract | Full Text | PDF  
N Engl J Med 2006; 355:2594-2595, Dec 14, 2006. Correspondence

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