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Volume 355:1177 September 14, 2006 Number 11
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Thyroxine in Goiter, H. pylori Infection, and Gastritis

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by Centanni, M.
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To the Editor: Centanni et al. (April 27 issue)1 describe conditions influencing the resorption of thyroxine and conclude that gastric acidity has a considerable effect on the bioavailability of iodothyronines. We do not share this opinion. In a recent crossover trial with healthy participants,2 we demonstrated that therapy with a high-dose proton-pump inhibitor (pantoprazole, 40 mg per day), resulting in elevated gastrin levels 1 week before the administration of thyroxine, did not influence absorption kinetics. The mechanisms of iodothyronine resorption are not fully understood, but malabsorption may be caused by numerous factors, including inflammatory diseases.3 In this context, it should . . . [Full Text of this Article]



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