The deepening of our understanding of normal biology has madeit clear that stem cells have a critical role not only in thegeneration of complex multicellular organisms, but also in thedevelopment of tumors. Recent findings support the concept thatcells with the properties of stem cells are integral to thedevelopment and perpetuation of several forms of human cancer.1,2,3Eradication of the stem-cell compartment of a tumor also maybe essential to achieve stable, long-lasting remission, andeven a cure, of cancer.4,5 Advances in our knowledge of theproperties of stem cells have made specific targeting and eradication. . . [Full Text of this Article]
Background and Definitions
Cancer Stem Cells in the Hematopoietic System
Cancer Stem Cells in the Central Nervous System
Cancer Stem Cells in the Breast
Challenges for Therapy Targeted against Cancer Stem Cells
Summary
Source Information
From the James P. Wilmot Cancer Center (C.T.J., M.L.G.) and the Department of Biomedical Genetics (M.N.), University of Rochester School of Medicine, Rochester, NY.
Address reprint requests to Dr. Jordan at the University of Rochester School of Medicine, 601 Elmwood Ave., Box 703, Rochester, NY 14642, or at craig_jordan@urmc.rochester.edu.
Related Letters:
Cancer Stem Cells
Wion D., Berger F., Jordan C. T., Guzman M. L., Noble M.
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N Engl J Med 2006;
355:2703, Dec 21, 2006.
Correspondence
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[Full Text]
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