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A 42-year-old woman with metastatic melanoma presented with a 1-month history of dyspnea and wheezing. The diagnosis of malignant melanoma had been made 6 years earlier on the basis of a biopsy of an enlarging mole on her left foot. The melanoma was 8.5 mm in depth, Clark level V, without involvement of the regional lymph nodes (stage II disease). One year before the current presentation, liver and bone metastases were diagnosed, and therapy with temozolomide was initiated, with a good response. Treatment with this agent was ongoing at the time of the current presentation. Pulmonary-function testing showed preserved total . . . [Full Text of this Article] |
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