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Clinical Implications of Basic Research
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Volume 355:1383-1385 September 28, 2006 Number 13
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Key Role for a Viral Lytic Gene in Kaposi's Sarcoma
Robert Yarchoan, M.D.

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Several types of cancer, including the majority of those typically associated with AIDS, are caused by gammaherpesviruses. Herpesviruses undergo both latent and lytic infection; most research on herpesvirus-induced tumors has focused on genes that mediate latency. However, a recent study by Grisotto et al.1 shows that a lytic gene of human herpesvirus 8 (HHV-8), also known as Kaposi's sarcoma–associated herpesvirus, may play a critical role in the development of Kaposi's sarcoma through direct and indirect mechanisms. This study highlights the role of lytic genes in viral oncogenesis.

The induction of tumors by viruses is best viewed as a biologic accident . . . [Full Text of this Article]


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From the HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD.



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