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Volume 355:1392-1395 September 28, 2006 Number 13
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Retinol-Binding Protein 4 and Insulin Resistance

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 by Graham, T. E.
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To the Editor: Graham et al. (June 15 issue)1 report that serum levels of retinol-binding protein 4 (RBP4) correlated with the magnitude of insulin resistance in various subjects. However, RBP4 and plasma insulin levels were dissociated in subjects who did not have an improvement in insulin sensitivity after exercise.1 Thus, we believe that the importance of RBP4 should be assessed in more diverse groups.

We assessed serum RBP4 levels in 473 subjects with normal glucose tolerance (fasting blood glucose level, <110 mg per deciliter) who were randomly selected from the Suita Study, an epidemiologic cohort study.2 Serum RBP4 levels correlated . . . [Full Text of this Article]


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