To the Editor: Graham et al. (June 15 issue)1 report that serumlevels of retinol-binding protein 4 (RBP4) correlated with themagnitude of insulin resistance in various subjects. However,RBP4 and plasma insulin levels were dissociated in subjectswho did not have an improvement in insulin sensitivity afterexercise.1 Thus, we believe that the importance of RBP4 shouldbe assessed in more diverse groups.
We assessed serum RBP4 levels in 473 subjects with normal glucosetolerance (fasting blood glucose level, <110 mg per deciliter)who were randomly selected from the Suita Study, an epidemiologiccohort study.2 Serum RBP4 levels correlated . . . [Full Text of this Article]
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