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Correspondence
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Volume 355:1396-1397 September 28, 2006 Number 13
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Alemtuzumab for Refractory Celiac Disease

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To the Editor: Vivas et al. (June 8 issue)1 describe a patient with refractory celiac disease who had a response to treatment with alemtuzumab. It is not clear whether the percentage of aberrant intraepithelial lymphocytes decreased while the patient was receiving alemtuzumab, since only {gamma}{delta} T cells are mentioned. However, the aberrant T-cell population (CD7+CD3–CD4–CD8– cytoplasmic CD3+) determines the risk of enteropathy-associated T-cell lymphoma. This population is distinct from the population of {gamma}{delta} T cells.2,3

We report on a 66-year-old woman who had refractory celiac disease with progressively more aberrant intraepithelial lymphocytes despite treatment with alemtuzumab. The patient had been on a . . . [Full Text of this Article]


Related Letters:

Alemtuzumab for Refractory Celiac Disease in a Patient at Risk for Enteropathy-Associated T-Cell Lymphoma
Vivas S., de Morales J. M. R., Ramos F., Suárez-Vilela D.
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N Engl J Med 2006; 354:2514-2515, Jun 8, 2006. Correspondence

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