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Correspondence
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Volume 355:1614-1615 October 12, 2006 Number 15
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Doxycycline for the Prevention of Tick-Borne Relapsing Fever

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by Hasin, T.
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To the Editor: In their article, Hasin et al. (July 13 issue)1 state that a 5-day course of doxycycline is safe and efficacious for the prevention of tick-borne relapsing fever (TBRF) in a person who has been bitten by an infected tick. We dispute both points. Healthy male soldiers, who were the subjects in the study, are not an appropriate population for determining drug safety. General travelers are a more suitable study group for this purpose. A survey of 383 Australian tourists taking doxycycline (100 mg daily) as chemoprophylaxis against malaria found that 15% reported nausea and vomiting, 12% reported . . . [Full Text of this Article]



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