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Case Records of the Massachusetts General Hospital
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Volume 355:1715-1722 October 19, 2006 Number 16
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Case 32-2006 — A 3-Year-Old Girl with Fever after a Visit to Africa
Iain P. Fraser, M.B., Ch.B., D.Phil., Christine M. Cserti, M.D., and Walter H. Dzik, M.D.

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Presentation of Case

Dr. Christine M. Cserti: A 3-year-old girl was admitted to this hospital because of fever and parasites in the peripheral blood.

Three weeks earlier, the patient and her 5-year-old brother and mother had traveled to Nigeria to visit relatives. Antimalarial chemoprophylaxis had been prescribed for the patient's mother but not for the children. They stayed in an urban hotel, were not near standing water, did not travel in the countryside, and did not recall any mosquito bites. When they returned to the United States, 5 days before admission, fever, rigors, lethargy, nausea, and vomiting developed in both children. The patient . . . [Full Text of this Article]

Differential Diagnosis

Discussion of Management

Antimalarial Prophylaxis

Treatment of P. falciparum Malaria

Severe Malaria and Exchange Transfusion

Anatomical Diagnosis


Source Information

From the Department of Pediatrics (I.P.F.) and the Blood Transfusion Service (C.M.C., W.H.D.), Massachusetts General Hospital; and the Departments of Pediatrics (I.P.F.) and Pathology (C.M.C., W.H.D.), Harvard Medical School.


Related Letters:

Case 32-2006: A Girl with Fever after a Visit to Africa
Williams J., Agarwal R., Srinivas R., Nath A., Blazes D. L., Sanders J. W., Riddle M. S., Pasvol G., Fraser I. P., Cserti C. M., Dzik W. H.
Extract | Full Text | PDF  
N Engl J Med 2007; 356:527-529, Feb 1, 2007. Correspondence

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