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Correspondence
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Volume 355:1736-1737 October 19, 2006 Number 16
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Counseling plus Buprenorphine–Naloxone for Opioid Dependence

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by Fiellin, D. A.
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To the Editor: Two points in the report by Fiellin et al. (July 27 issue)1 on the use of counseling plus buprenorphine–naloxone maintenance therapy for opioid dependence warrant further discussion. First, the authors report that patients' adherence to treatment with buprenorphine–naloxone correlated significantly with the outcome. It would be informative to know what the relationship was between adherence to counseling and the treatment outcome. My colleagues and I recently reported on adherence to counseling in a clinical trial of buprenorphine for the treatment of combined opioid and cocaine dependence in medication-adherent patients.2 There was a significant positive association between adherence . . . [Full Text of this Article]



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