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FOCUS ON RESEARCH Previous Volume 355:1759-1761 October 26, 2006 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The Wiskott–Aldrich syndrome is a well-recognized triad of eczema, bleeding diathesis, and recurrent infections that occurs in boys. Although it is rare (with an estimated incidence of less than 1 in 100,000 births), the syndrome offers rich historical, clinical, and scientific lessons.

In a typical case of severe Wiskott–Aldrich syndrome, petechiae (see figure), bruising, and bloody diarrhea may develop in the first days of life owing to thrombocytopenia with small platelets (low platelet volume). Unusually prolonged bleeding after circumcision often leads to the discovery of the thrombocytopenia. Eczema — which may be severe — ensues, and throughout childhood there . . . [Full Text of this Article]

Source Information

Dr. Puck is a professor in the Department of Pediatrics, University of California, San Francisco, San Francisco. Dr. Candotti is a senior investigator in the Genetics and Molecular Biology Branch of the Human Genome Research Institute, National Institutes of Health, Bethesda, MD.

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