Imagine you had a database of the gene-expression signaturesof human diseases and their responses to therapeutic drugs.Its use could result in an unprecedented understanding of theinterconnectivity of disease pathways and might also lead tothe rational design of an optimal treatment or uncover new strategiesfor treating disease. Such a crystal ball does not yet exist,but a report by Lamb et al.1 offers a glimpse of this visionin a laboratory setting.
The traditional approach to developing new therapeutic drugsinvolves the painstaking identification of an individual drugtarget, such as a receptor or ion channel, . . . [Full Text of this Article]
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