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Volume 355:2158-2159 November 16, 2006 Number 20
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Atazanavir Urolithiasis

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To the Editor: Atazanavir sulfate, a protease inhibitor, is indicated in combination with other antiretroviral agents for the treatment of HIV type 1 (HIV-1) infection.1 Among the antiretroviral agents that are currently in use, only indinavir is known to cause kidney stones.2 We describe a patient who had hydronephrosis and a ureteral stone composed mainly of atazanavir metabolites.

A 44-year-old man with HIV infection presented with abdominal pain, chills, nausea and vomiting, and a decreased oral intake of fluids. His CD4 count was 70 cells per cubic millimeter, and his HIV-1 RNA level was less than 75 copies per milliliter. . . . [Full Text of this Article]


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