To the Editor: Atazanavir sulfate, a protease inhibitor, isindicated in combination with other antiretroviral agents forthe treatment of HIV type 1 (HIV-1) infection.1 Among the antiretroviralagents that are currently in use, only indinavir is known tocause kidney stones.2 We describe a patient who had hydronephrosisand a ureteral stone composed mainly of atazanavir metabolites.
A 44-year-old man with HIV infection presented with abdominalpain, chills, nausea and vomiting, and a decreased oral intakeof fluids. His CD4 count was 70 cells per cubic millimeter,and his HIV-1 RNA level was less than 75 copies per milliliter.. . . [Full Text of this Article]
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