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Editorial
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Volume 355:2252-2253 November 23, 2006 Number 21
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Research Replication
Jeffrey M. Drazen, M.D.

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 by Hiatt, W. R.
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In January 2006, we published an article by Mangano and colleagues1 that reported the results of an observational study of antifibrinolytic agents to control bleeding in cardiac surgery. The data suggested that patients treated with aprotinin, as compared with no antifibrinolytic agent, aminocaproic acid, or tranexamic acid, had higher risks of a number of adverse events, including cardiovascular events (myocardial infarction, heart failure, and stroke) and renal failure requiring dialysis. The study data were from a prospective registry funded by the Ischemia Research and Education Foundation. As detailed by Hiatt in a Perspective article in this issue of the Journal, . . . [Full Text of this Article]


Related Letters:

Judging the Safety of Aprotinin
Mangano D. T., Rieves R. D., Weiss K. D.
Extract | Full Text | PDF  
N Engl J Med 2006; 355:2261-2262, Nov 23, 2006. Correspondence



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