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Previous Volume 355:2254-2255 November 23, 2006 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Aging and stress, stress and aging — these two human conditions, when paired, can profoundly affect the quality of life. When events go awry, molecular processes take place that, over time, can lead to neurodegenerative disease. At the root of the problem is a fundamental process: protein folding. Since proteins are the predominant products of gene expression and provide much of the shape and functionality of the cell, their proper synthesis, folding, assembly, translocation, and clearance are essential for the health of the cell and the organism. When proteins misfold, they can acquire alternative proteotoxic states that seed a cascade . . . [Full Text of this Article]

Source Information

From the Department of Biochemistry, Molecular Biology, and Cell Biology, Rice Institute for Biomedical Research, Northwestern University, Evanston, IL.

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