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Volume 355:2256 November 23, 2006 Number 21
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Deep-Brain Stimulation for Parkinson's Disease

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by Deuschl, G.
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To the Editor: We are impressed by the favorable outcome of deep-brain stimulation, as compared with optimal medical management alone, for levodopa-related motor complications of advanced Parkinson's disease in the study reported by Deuschl et al. (Aug. 31 issue).1 However, we disagree with the conclusion that cognition, mood, and overall psychiatric functioning were unchanged by neurostimulation. One patient in the treatment group but none in the control group committed suicide; seven patients in the treatment group but none in the control group had depressive symptoms or cognitive disturbances. The exact nature or putative causes of these adverse events are not . . . [Full Text of this Article]



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