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Previous Volume 355:2475-2477 December 7, 2006 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In patients with acute myocardial infarction, the prompt restoration of antegrade flow in the infarct-related coronary artery, whether accomplished pharmacologically¹ or mechanically,² improves left ventricular systolic function and reduces mortality. Initially, these salutary effects of reperfusion therapy were thought to be tightly linked: successful reperfusion salvaged ischemic but still viable myocardium, which led to improved left ventricular function and, in turn, improved survival. Conversely, reperfusion of the infarct-related artery more than 12 hours after the onset of infarction was thought not to achieve these beneficial results. However, several studies suggested that the effects of reperfusion on left ventricular function and . . . [Full Text of this Article]

Source Information

From the Department of Medicine (Cardiovascular Division), University of Texas Southwestern Medical Center, Dallas (L.D.H.); and the Department of Medicine (Cardiovascular Division), Johns Hopkins Medical Institutions, Baltimore (R.A.L.).

This article was published at www.nejm.org on November 14, 2006.

Related Letters:

Persistent Coronary Occlusion after Myocardial Infarction
Anderson J. R., Nagajothi N., Velazquez-Cecena J.-L. E., Khosla S., Wong B., Erdogan O., De Luca L., Tomai F., Chua D., Lo A., Kuo I. F., Hochman J. S., Forman S., Reynolds H. R., the Occluded Artery Trial Investigators , Hillis L. D., Lange R. A.
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N Engl J Med 2007; 356:1681-1684, Apr 19, 2007. Correspondence

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