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Correspondence
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Volume 355:2599-2600 December 14, 2006 Number 24
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Hormone Replacement and the Risk of Breast Cancer in Turner's Syndrome

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To the Editor: Turner's syndrome is characterized by estrogen deficiency due to nonfunctioning bilateral streaks of fibrous stroma.1 The benefit of hormone-replacement therapy in patients with this disorder has been well demonstrated. An increased risk of breast cancer in healthy postmenopausal women who receive more than 5 years of hormone-replacement therapy has been reported,2 but data from studies in patients with Turner's syndrome are scarce. However, concern about such patients, which has been raised by an extrapolation of findings from studies involving postmenopausal women, appears to be unwarranted.3

We report on 62 patients with Turner's syndrome and 3 patients with . . . [Full Text of this Article]



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