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Previous Volume 355:513-515 August 3, 2006 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Approximately 1.1 million Americans have an acute myocardial infarction each year. The size of the infarction is a major determinant of both the risk of death and the likelihood of subsequent heart failure. For this reason, a goal of therapy is to reduce the size of the infarct. Current treatments focus on restoration of coronary blood flow (through reperfusion) and reduction of myocardial oxygen demand (e.g., through the use of beta-blockers). Research during the past two decades, however, has tried to elucidate the critical steps in the injury and subsequent killing of myocardial cells, with the hope that antagonizing these . . . [Full Text of this Article]

Source Information

From the Departments of Medicine and Cell Biology, Cardiovascular Research Center and Cancer Center, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, N.Y. (R.N.K.); and the Departments of Pathology and Medicine, University of California, Davis, Davis (I.J.).

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