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Case Records of the Massachusetts General Hospital
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Volume 355:602-611 August 10, 2006 Number 6
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Case 24-2006 — A 40-Year-Old Woman with Hypotension after an Overdose of Amlodipine
N. Stuart Harris, M.D., M.F.A.

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Presentation of Case

Dr. Murray McLachlan (Emergency Medicine): A 40-year-old woman was transferred to the emergency department of this hospital because of hypotension. She had been well until the early afternoon of the day of admission, when she left the physician's office where she worked and went home, saying that she did not feel well. At approximately 4:30 p.m., her husband arrived home and found her pale and groggy. She told him that she had ingested 100 sample tablets of amlodipine (10 mg, not specified as standard or sustained release) at the office at about 12:30 p.m., in a suicide attempt. Her husband . . . [Full Text of this Article]

Management

Emergency Care of the Poisoned Patient

Management of Overdose of Calcium-Channel Blockers

            Basic Principles

            Chemical Classes of Calcium-Channel Blockers

            Volume Replacement

            Calcium Therapy

            Circulatory Support

            Hyperinsulinemia–Euglycemia Therapy

            Adrenergic-Receptor Stimulation

            Toxin Removal

            Mechanical Support

Follow-up

Final Diagnosis


Source Information

From the Department of Emergency Medicine, Massachusetts General Hospital, and the Department of Surgery, Harvard Medical School.


Related Letters:

Case 24-2006: A Woman with Hypotension after an Overdose of Amlodipine
Aggarwal C., Gupta S., Erickson C. P., Thompson T. M., Bryant S. M., Lu J. J., Harris N. S., Fagenholz P. J.
Extract | Full Text | PDF  
N Engl J Med 2006; 355:1936-1938, Nov 2, 2006. Correspondence

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