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Previous Volume 355:730-732 August 17, 2006 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Why study hereditary periodic-fever syndromes, which affect fewer than 500 patients worldwide? The discovery of cryopyrin provides an answer. The story begins in 2001, when investigators showed that mutations in the cold-induced autoinflammatory syndrome 1 (CIAS1) gene, which encodes cryopyrin, causes two hereditary periodic-fever disorders: the Muckle–Wells syndrome and the familial cold autoinflammatory syndrome.¹ The following year, a third periodic-fever syndrome (also referred to as neonatal-onset multisystem inflammatory disease or the chronic infantile neurologic, cutaneous, articular syndrome) was found to be caused by mutant cryopyrin.^2,3 Three articles recently published in Nature^4,5,6 now suggest that by discovering cryopyrin, the . . . [Full Text of this Article]

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From the Departments of Gastroenterology, Hepatology, and General Internal Medicine, Radboud University Medical Center, Nijmegen, the Netherlands.

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