FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 355:809-817 August 24, 2006 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text PowerPoint Slide Set Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors' clinical recommendations.

A 63-year-old man with coronary artery disease who has recently undergone bypass surgery presents with dyspnea. Findings on physical examination are unremarkable. Laboratory testing reveals a platelet count of 86,000 per cubic millimeter, as compared with 225,000 per cubic millimeter at the time of discharge nine days earlier. The results of chest radiography are unremarkable; spiral computed tomography of the chest shows . . . [Full Text of this Article]

The Clinical Problem

Strategies and Evidence

Incidence

Clinical Diagnosis

Laboratory Diagnosis

Management

            Other Therapies

            Duration of Therapy and Use of Oral Anticoagulants

Areas of Uncertainty

Guidelines

Conclusions and Recommendations

Source Information

From the Department of Medicine, Division of Hematology (G.M.A., T.L.O.), and the Department of Pathology (T.L.O.), Duke University Medical Center, Durham, N.C.

Address reprint requests to Dr. Ortel at the Hemostasis and Thrombosis Center, Duke University Health System, Box 3422, Stead Bldg., Rm. 0563, Durham, NC 27710, or at thomas.ortel@duke.edu.

Related Letters:

Heparin-Induced Thrombocytopenia
Saad R. A., Arepally G. M., Ortel T. L.
Extract | Full Text | PDF  
N Engl J Med 2006; 355:2598-2599, Dec 14, 2006. Correspondence

This article has been cited by other articles:

• Konstantinides, S. (2008). Acute Pulmonary Embolism. NEJM 359: 2804-2813 [Full Text]  
• Selleng, S., Haneya, A., Hirt, S., Selleng, K., Schmid, C., Greinacher, A. (2008). Management of anticoagulation in patients with subacute heparin-induced thrombocytopenia scheduled for heart transplantation. Blood 112: 4024-4027 [Abstract] [Full Text]  
• Kittisupamongkol, W. (2008). Incidence and Prognostic Significance of Thrombocytopenia in Patients Receiving Heparin Therapy. Arch Intern Med 168: 2170-2170 [Full Text]  
• Philip, A., Ramchandani, S., Dorrance, K., Dorrance, C. (2008). Sildenafil-Induced Thrombocytopenia. ANN INTERN MED 149: 437-439 [Full Text]  
• Smythe, M. A., Koerber, J. M., Fitzgerald, M., Mattson, J. C. (2008). The Financial Impact of Heparin-Induced Thrombocytopenia. Chest 134: 568-573 [Abstract] [Full Text]  
• Phillips, K. W., Dobesh, P. P., Haines, S. T. (2008). Considerations in using anticoagulant therapy in special patient populations. Am J Health Syst Pharm 65: S13-S21 [Abstract] [Full Text]  
• Zlotnick, A. Y., Shehadeh, J., Flugelman, M. Y., Bursztein-De Myttenaere, S. A., Gaspar, T., Shiran, A. (2008). Acute Reversible Bioprosthetic Mitral Valve Stenosis Caused by Heparin-Induced Thrombocytopenia. Circulation 118: e73-e75 [Full Text]  
• Warkentin, T. E., Greinacher, A., Koster, A., Lincoff, A. M. (2008). Treatment and Prevention of Heparin-Induced Thrombocytopenia: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 133: 340S-380S [Abstract] [Full Text]  
• Moll, S. (2008). A Clinical Perspective of Venous Thromboembolism. Arterioscler. Thromb. Vasc. Bio. 28: 373-379 [Full Text]  
• Barzaghi, N., Locatelli, A., Ranucci, M. (2008). Ventricular Assist Device Implantation and the Risk for Heparin-Induced Thrombocytopenia. Ann. Thorac. Surg. 85: 360-361 [Full Text]  
• Suvarna, S., Espinasse, B., Qi, R., Lubica, R., Poncz, M., Cines, D. B., Wiesner, M. R., Arepally, G. M. (2007). Determinants of PF4/heparin immunogenicity. Blood 110: 4253-4260 [Abstract] [Full Text]  
• Kerendi, F., Thourani, V. H., Puskas, J. D., Kilgo, P. D., Osgood, M., Guyton, R. A., Lattouf, O. M. (2007). Impact of Heparin-Induced Thrombocytopenia on Postoperative Outcomes After Cardiac Surgery. Ann. Thorac. Surg. 84: 1548-1555 [Abstract] [Full Text]  
• Szabo, S., Oikonomopoulos, T., Hoffmeister, H. M., Lange, M., Van Aken, H., Westphal, M., Kumar, P. D., Detry, O., De Roover, A., Honore, P., Mannucci, P. M., Levi, M. (2007). Prevention and Treatment of Major Blood Loss. NEJM 357: 1260-1261 [Full Text]  
• Levy, J. H., Tanaka, K. A., Hursting, M. J. (2007). Reducing Thrombotic Complications in the Perioperative Setting: An Update on Heparin-Induced Thrombocytopenia. Anesth. Analg. 105: 570-582 [Abstract] [Full Text]  
• Aster, R. H., Bougie, D. W. (2007). Drug-Induced Immune Thrombocytopenia. NEJM 357: 580-587 [Full Text]  
• Schneider, D. J., Sobel, B. E. (2007). Conundrums in the Combined Use of Anticoagulants and Antiplatelet Drugs. Circulation 116: 305-315 [Full Text]  
• Warkentin, T. E., Eikelboom, J. W. (2007). Who Is (Still) Getting HIT?. Chest 131: 1620-1622 [Full Text]  
• Hutchison, C. A., Dasgupta, I. (2007). National survey of heparin-induced thrombocytopenia in the haemodialysis population of the UK population. Nephrol Dial Transplant 22: 1680-1684 [Abstract] [Full Text]  
• Smythe, M. A., Koerber, J. M., Mattson, J. C. (2007). The Incidence of Recognized Heparin-Induced Thrombocytopenia in a Large, Tertiary Care Teaching Hospital. Chest 131: 1644-1649 [Abstract] [Full Text]  
• De Caterina, R., Husted, S., Wallentin, L., Agnelli, G., Bachmann, F., Baigent, C., Jespersen, J., Kristensen, S. D., Montalescot, G., Siegbahn, A., Verheugt, F. W.A., Weitz, J. (2007). Anticoagulants in heart disease: current status and perspectives. Eur Heart J 0: ehl492v1-34 [Full Text]  
• Bazari, H., Jaff, M. R., Mannstadt, M., Yan, S. (2007). Case 7-2007 -- A 59-Year-Old Woman with Diabetic Renal Disease and Nonhealing Skin Ulcers. NEJM 356: 1049-1057 [Full Text]  
• Saad, R. A., Arepally, G. M., Ortel, T. L. (2006). Heparin-Induced Thrombocytopenia. NEJM 355: 2598-2599 [Full Text]