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Previous Volume 355:950-952 August 31, 2006 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In late September 2004, the cardiovascular risks identified in a placebo-controlled adenoma-prevention trial that was terminated early precipitated the voluntary withdrawal from the market of the cyclooxygenase-2 (COX-2) inhibitor rofecoxib.¹ Later that year, in another adenoma-prevention trial, the COX-2 inhibitor, celecoxib, was also associated with an increase in the risk of cardiovascular events.² For this reason, on December 17, 2004, the data and safety monitoring boards of two celecoxib trials recommended stopping drug administration in the trials.^2,3 Articles describing the cardiovascular risks seen in the two adenoma prevention trials were published rapidly.^1,4 However, in the absence of evidence about the . . . [Full Text of this Article]

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From the Cardiovascular Health Research Unit, Departments of Medicine (B.M.P.), Epidemiology (B.M.P., J.D.P.), and Health Services (B.M.P.), University of Washington; and the Division of Public Health Sciences, Fred Hutchinson Cancer Research Center (J.D.P.) — both in Seattle.

Related Letters:

Risks and Benefits of Celecoxib to Prevent Colorectal Adenomas
Andersohn F., Suissa S., Garbe E., Solomon S., Wittes J., Arber N., Bertagnolli M., Hawk E., Levin B., the APC and PreSAP Trial Investigators , Psaty B. M., Potter J. D.
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N Engl J Med 2006; 355:2371-2373, Nov 30, 2006. Correspondence

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