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Volume 355:960 August 31, 2006 Number 9
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Microarray Analysis and Tumor Classification

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by Quackenbush, J.
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To the Editor: Quackenbush (June 8 issue)1 provides a comprehensive review of microarray technology within the framework of clinical application and also addresses some limitations of molecular analyses. A consideration not mentioned in the review is that the process of acquiring tissues for molecular analyses may result in important changes in gene expression, independent of disease biology. For example, we found that significant alterations in transcription factors occur simply as a result of surgical excision of the prostate.2 Those interpreting the results of molecular analyses of surgical samples should recognize that such alterations occur rapidly and may be associated with . . . [Full Text of this Article]



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