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Volume 356:87-89 January 4, 2007 Number 1
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Transmission of Human Herpesvirus 8 by Blood Transfusion

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by Blajchman, M. A.
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by Hladik, W.
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To the Editor: Hladik and colleagues (Sept. 28 issue)1 provide evidence of human herpesvirus 8 (HHV-8) transmission by blood transfusion. They suggest that HHV-8 blood screening for immunocompromised patients may be warranted. However, their statement that nucleic acid testing would not be effective for blood-bank screening is debatable. The viral load is an important marker of disease activity for a number of viruses, including the human immunodeficiency virus (HIV), cytomegalovirus, and HHV-8. By contrast, the clinical significance of seroreactivity to HHV-8 antigens is not clear.2 Reliable techniques to detect HHV-8 DNA have been developed.2 One would expect patients with HHV-8 . . . [Full Text of this Article]



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