FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 356:1169-1171 March 15, 2007 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Perspective by Christensen, K. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

The completion of the Human Genome Project was a remarkable feat and provided 3 billion bases of reference nucleotides for comparative studies. An analogy often used to conceptualize human genetic information is that of an encyclopedia, in which each volume of the set would represent 1 of the 23 pairs of human chromosomes. Sections within each volume would represent the (approximately) 25,000 genes of the human genome, and letters of the alphabet would represent the individual bases of DNA encoding specific amino acids that are the building blocks of proteins. To date, the molecular medicine model that is promulgated in . . . [Full Text of this Article]

Source Information

From the Departments of Molecular and Human Genetics and Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston.

This article has been cited by other articles:

• Hardy, J., Singleton, A. (2009). Genomewide Association Studies and Human Disease. NEJM 360: 1759-1768 [Full Text]  
• Lu, X.-Y., Phung, M. T., Shaw, C. A., Pham, K., Neil, S. E., Patel, A., Sahoo, T., Bacino, C. A., Stankiewicz, P., Kang, S.-H. L., Lalani, S., Chinault, A. C., Lupski, J. R., Cheung, S. W., Beaudet, A. L. (2008). Genomic Imbalances in Neonates With Birth Defects: High Detection Rates by Using Chromosomal Microarray Analysis. Pediatrics 122: 1310-1318 [Abstract] [Full Text]  
• Cusco, I., Corominas, R., Bayes, M., Flores, R., Rivera-Brugues, N., Campuzano, V., Perez-Jurado, L. A. (2008). Copy number variation at the 7q11.23 segmental duplications is a susceptibility factor for the Williams-Beuren syndrome deletion. Genome Res 18: 683-694 [Abstract] [Full Text]  
• Hardy, J., Singleton, A. (2008). The HapMap: Charting a Course for Genetic Discovery in Neurological Diseases. Arch Neurol 65: 319-321 [Abstract] [Full Text]  
• Weiss, L. A., Shen, Y., Korn, J. M., Arking, D. E., Miller, D. T., Fossdal, R., Saemundsen, E., Stefansson, H., Ferreira, M. A.R., Green, T., Platt, O. S., Ruderfer, D. M., Walsh, C. A., Altshuler, D., Chakravarti, A., Tanzi, R. E., Stefansson, K., Santangelo, S. L., Gusella, J. F., Sklar, P., Wu, B.-L., Daly, M. J., the Autism Consortium, (2008). Association between Microdeletion and Microduplication at 16p11.2 and Autism. NEJM 358: 667-675 [Abstract] [Full Text]  
• von Ahsen, N., Oellerich, M. (2007). Chip-Based Genotyping: Translation of Pharmacogenetic Research to Clinical Practice. Clin. Chem. 53: 1186-1187 [Full Text]