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Volume 356:1276-1277 March 22, 2007 Number 12
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Statins and the Effect of BCG on Bladder Cancer

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To the Editor: Hoffmann and colleagues (Dec. 21 issue)1 report on the use of statins and the outcome of immunotherapy with bacille Calmette–Guérin (BCG) vaccine in 84 patients with superficial bladder cancer. The authors report that over a median follow-up period of 46 months, 19 patients who were using statins had an increased risk of "more aggressive" disease.

We analyzed outcomes in a cohort of 156 patients (median follow-up, 56 months) who received BCG; 39 used statins during the treatment, and 117 did not. We found no significant differences between the two groups in the incidence of tumor recurrence (59% . . . [Full Text of this Article]


Related Letters:

Use of Statins and Outcome of BCG Treatment for Bladder Cancer
Hoffmann P., Roumeguère T., Schulman C., van Velthoven R.
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N Engl J Med 2006; 355:2705-2707, Dec 21, 2006. Correspondence



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