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Previous Volume 356:1445-1454 April 5, 2007 Number 14 Next

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Hepatitis C virus (HCV) and hepatitis B virus (HBV) infections are common among patients with human immunodeficiency virus (HIV) infection because of shared routes of viral transmission. Liver disease due to chronic HBV and HCV infection is becoming a leading cause of death among persons with HIV infection worldwide, and the risk of death related to liver disease is inversely related to the CD4 cell count (Figure 1).^1,2 There is also an increase in the incidence of hepatocellular carcinoma and hepatotoxic effects associated with antiretroviral drugs in patients with HCV and HBV coinfection.^1,3,4,5,6 New treatments for both HCV . . . [Full Text of this Article]

Epidemiology

Preventing Viral Hepatitis and Minimizing Disease

HCV Infection

Assessment of Liver Injury

Treatment in Patients with HIV and HCV Coinfection

HBV Infection

Treatment in Patients with HIV and HBV Coinfection

Future Treatments for Hepatitis

Source Information

From the Division of Infectious Disease, Beth Israel Deaconess Medical Center, and Harvard Medical School — both in Boston (M.J.K.); and the Division of Gastroenterology, University of California at San Francisco, San Francisco (M.G.P.).

Address reprint requests to Dr. Koziel at the Harvard Institutes of Medicine, Rm. 223a, 330 Brookline Ave., Boston, MA 02215, or at mkoziel@bidmc.harvard.edu.

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