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Previous Volume 356:1479-1481 April 5, 2007 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In their Medical Progress article on Whipple's disease, Fenollar and colleagues (Jan. 4 issue)¹ raise important issues regarding culture-negative endocarditis. We report on a 38-year-old-man with a 6-month history of polyarthralgia. He had clubbing of the fingers as well as aortic and mitral regurgitant murmurs. Transesophageal echocardiography showed vegetations on both the mitral and aortic (bicuspid) valves. Multiple blood cultures and routine serologic tests were negative. A species-specific polymerase-chain-reaction (PCR) assay for Tropheryma whipplei and broad-range PCR for 16S ribosomal DNA² on whole blood were negative.

After replacement of the aortic and mitral valves, tissue samples from . . . [Full Text of this Article]

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