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Previous Volume 356:1887-1888 May 3, 2007 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Liu et al. (Jan. 18 issue)¹ report on a 186-gene "invasiveness" gene signature (IGS) that discriminates between normal breast epithelium and tumorigenic breast-cancer cells that are characterized by CD44 expression and low or undetectable levels of CD24. This signature is associated with survival among patients with breast cancer. We profiled 200 breast tumors with the use of DNA microarrays and determined their molecular subtype. We used the 186-gene IGS to classify the basal and the luminal samples. The two subtypes were well separated. We found that 89% of genes that were overexpressed in cancer stem cells were . . . [Full Text of this Article]

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