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Previous Volume 356:1996-1997 May 10, 2007 Number 19 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Three recent reports^1,2,3 have shown that cancers in mice can be eliminated through the activation of a single gene, Tp53, which encodes the protein p53. The power of p53 with respect to killing cancer cells had been suspected for decades, but the elimination of malignant tumors by the activation of p53 had not been observed.

The p53 protein is arguably the most important sensor of stress that mammals possess. Under normal, basal conditions, this protein is inconsequential, because of the rapidity of its degradation. But almost any type of stress, including damage to DNA and oncogenic signaling, halts the . . . [Full Text of this Article]

Source Information

From the Spanish National Cancer Research Center, Madrid.

This article has been cited by other articles:

• Welch, H. G., Woloshin, S., Schwartz, L. M. (2008). The Sea of Uncertainty Surrounding Ductal Carcinoma In Situ--The Price of Screening Mammography. JNCI J Natl Cancer Inst 100: 228-229 [Full Text]  
• Welch, H. G., Woloshin, S., Schwartz, L. M., Gordis, L., Gotzsche, P. C., Harris, R., Kramer, B. S., Ransohoff, D. F. (2007). Overstating the Evidence for Lung Cancer Screening: The International Early Lung Cancer Action Program (I-ELCAP) Study. Arch Intern Med 167: 2289-2295 [Abstract] [Full Text]  
• Ferretti, G, Felici, A, Cognetti, F (2007). The other side of p53. Ann Oncol 18: 1425-1426 [Full Text]