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Volume 356:189-191 January 11, 2007 Number 2
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Refining Prognosis in Non–Small-Cell Lung Cancer

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by Potti, A.
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To the Editor: Potti et al. (Aug. 10 issue)1 apply a metagene model to the profiling of non–small-cell lung cancer (NSCLC) and demonstrate superior performance in predicting tumor recurrence and survival, as compared with a clinical model. We believe that the impressively contrasting results could be partially due to the incompleteness of the clinical model the authors used. Classifying NSCLC into squamous-cell carcinoma and adenocarcinoma has not been predictive for prognosis in general. However, subtypes of adenocarcinoma — bronchioloalveolar carcinoma and mixed adenocarcinoma with a bronchioloalveolar component, which account for approximately 20% of cases of early-stage NSCLC — have a . . . [Full Text of this Article]



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