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A 20-year-old woman with asthma was taken to the emergency room of another hospital because of cardiorespiratory arrest. The patient had had severe asthma since childhood. She was born after a normal pregnancy and delivery to a teenaged, single mother, who smoked three packs of cigarettes per day during pregnancy and during the patient's childhood. Asthma developed at the age of 4 years, and exacerbations occurred frequently thereafter, triggered by cold air, hot humid air, physical activity, respiratory infections, anxiety, and exposures to paint and to cats and birds that were kept in her home or the homes of relatives.
Differential Diagnosis
Discussion of Management
Managing Severe Asthma
Adherence to Controller Therapy and Appropriate Technique
Consistent Physician Care
Education and Warning Signs
Other Medical Options
Factors Contributing to Poor Outcomes despite Optimal Medication Regimens
Pharmacogenetics and the Efficacy of Asthma Therapies
Use of Biomarkers in Asthma Control
Dr. Michael E. Wechsler's Diagnosis
Pathological Discussion
Anatomical Diagnosis
Source Information
From the Division of Pulmonary and Critical Care, Department of Medicine, Brigham and Women's Hospital (M.E.W.); the Departments of Radiology (J.-A.O.S.) and Pathology (E.J.M.), Massachusetts General Hospital; and the Departments of Medicine (M.E.W.), Radiology (J.-A.O.S.), and Pathology (E.J.M.), Harvard Medical School — all in Boston.
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