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Correspondence
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Volume 356:2104-2106 May 17, 2007 Number 20
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Air Pollution and Cardiovascular Events

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by Miller, K. A.
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To the Editor: In the report by Miller and colleagues on long-term exposure to air pollution and the incidence of cardiovascular events in women (Feb. 1 issue),1 the authors state that their robust findings (hazard ratio for death from cardiovascular disease, 1.76) cannot be explained by acute effects of particulate matter. Although particulate matter might subtly promote atherosclerosis,2 their findings in no way illustrate synergistic, long-term health consequences of exposure beyond acute effects.

The largest portion of the observed cardiovascular morbidity and mortality is due to particulate matter as a "triggering event" within hours to weeks after exposure. Cohort studies1 . . . [Full Text of this Article]


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