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Previous Volume 356:2195-2198 May 24, 2007 Number 21 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The compelling evidence that chronic use of aspirin or certain nonsteroidal antiinflammatory drugs (NSAIDs) can substantially lower the risk of colon cancer has important implications, especially because colon cancer is the second leading cause of cancer death. Aspirin and nonselective NSAIDs each inhibit the generation of prostaglandins by inhibiting the two cyclooxygenase (COX) enzymes that initiate prostaglandin synthesis, COX-1 and COX-2. NSAIDs that are selective for COX-2 also inhibit the generation of prostaglandins. COX-1 is constitutively expressed in the colon, but COX-2 is inducible and markedly up-regulated in many colon cancers. Interventional trials have shown a decreased risk of the . . . [Full Text of this Article]

Source Information

From the Department of Medicine and Ireland Cancer Center, Case Western Reserve University School of Medicine and Case Medical Center, Cleveland, and the Howard Hughes Medical Institute, Chevy Chase, MD.

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