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Previous Volume 356:2522-2524 June 14, 2007 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In this issue of the Journal, Nissen and Wolski¹ report the results of a meta-analysis of treatment trials of rosiglitazone, as compared either with other therapies for type 2 diabetes or with placebo. Eligible studies included randomized trials that lasted for at least 24 weeks. The prespecified primary end points of interest were myocardial infarction and death from cardiovascular causes. The authors identified 42 eligible studies, many of which were small or short-term trials, that included a total of 158 myocardial infarctions and 61 deaths from cardiovascular causes. They used the Peto method to combine data from the trials. In . . . [Full Text of this Article]

Source Information

From the Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, and the Center for Health Studies, Group Health, Seattle (B.M.P.); and the Division of Public Health Sciences, Wake Forest University, Winston-Salem, NC (C.D.F.).

This article (10.1056/NEJMe078099) was published at www.nejm.org on May 21, 2007.

Related Letters:

Rosiglitazone and Cardiovascular Risk
Bracken M. B., Mannucci E., Monami M., Marchionni N., Diamond G. A., Kaul S., Brett A. S., Nissen S. E., Wolski K., Psaty B. M., Furberg C. D.
Extract | Full Text | PDF  
N Engl J Med 2007; 357:937-940, Aug 30, 2007. Correspondence

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