The truly remarkable advances in the treatment of human immunodeficiencyvirus type 1 (HIV-1) infection have turned a once nearly uniformdeath sentence into a treatable condition. The survival benefitsresulting from the use of antiretroviral drugs are estimatedto have saved 3 million years of life; these benefits comparefavorably with those of many other interventions for chronicdiseases.1 In the 20 years since zidovudine was first approved,more than 20 other antiretroviral drugs have emerged, includinginhibitors of HIV-1 reverse transcriptase, protease, and attachmentand entry. Several other experimental agents now in expanded-accessprograms may be approved in . . . [Full Text of this Article]
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From the Department of Medicine, Massachusetts General Hospital, Boston, and the Partners AIDS Research Center, Cambridge, MA.
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