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Previous Volume 356:2644-2645 June 21, 2007 Number 25 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The search for the basic mechanisms responsible for the development and progression of heart failure has been exhaustive. Despite the elucidation of several clinically relevant signal transduction pathways that can lead to disease progression (e.g., those that activate the angiotensin and adrenergic signaling pathways), the means by which these pathways are coordinated with respect to the development and progression of heart failure remain obscure. A recent study by van Rooij and colleagues¹ is particularly welcome because it provides a new understanding of how stress responses are coordinated in the failing heart.

The heart responds to cardiac injury or hemodynamic overload . . . [Full Text of this Article]

Source Information

From the Winters Center for Heart Failure Research, Baylor College of Medicine, and the Texas Heart Institute at St. Luke's Episcopal Hospital — both in Houston.

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