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Correspondence
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Volume 356:2650-2652 June 21, 2007 Number 25
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Chikungunya Outbreaks

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by Charrel, R. N.
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To the Editor: In their Perspective article on outbreaks of chikungunya fever, Charrel et al. (Feb. 22 issue)1 suggest that the recent outbreak in India2 could have been caused by the same viral strain that caused the Indian Ocean outbreak.3 Recent data do not support this speculation.4,5 We previously described sequence microheterogeneity in the viruses causing the Indian Ocean outbreak.4 We have compared E1 sequences from viruses involved in the Indian and Indian Ocean outbreaks (Figure 1).4,5 The strains differed only in a single nucleotide change (T321C), which was found in all Indian Ocean isolates. Isolates from India . . . [Full Text of this Article]



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