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Volume 356:212 January 18, 2007 Number 3
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The Preventive Polypill — Much Promise, Insufficient Evidence
K. Srinath Reddy, M.D., D.M.

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The rapidly increasing global burdens of cardiovascular disease and diabetes call for interventions that have a population-wide effect, as well as interventions that identify and protect individual patients who have a high risk of major adverse events. Such actions are especially needed in low-income and middle-income countries, which can ill afford the huge losses in human and financial resources that will result from unchecked development of clinical disease.1

Many drugs have been found to be highly effective in the primary or secondary prevention of cardiovascular disease. These include aspirin, angiotensin-converting–enzyme (ACE) inhibitors, statins, beta-blockers, and calcium-channel blockers. Despite their potential . . . [Full Text of this Article]


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Dr. Reddy is the president of the Public Health Foundation of India and a professor of cardiology at the All India Institute of Medical Sciences, New Delhi.

An interview with Dr. Reddy can be heard at www.nejm.org.


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