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Previous Volume 356:416-418 January 25, 2007 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Schneider et al. (Oct. 12 issue)¹ conclude that the adverse effects of atypical antipsychotic drugs for the treatment of psychosis, aggression, and agitation in patients with Alzheimer's disease offset the advantages. However, they acknowledge that the doses used in the study were lower than some clinicians would have used and that patients could discontinue a study drug (a main outcome) and randomly switch to another of the study drugs. The rate of discontinuation of treatment ranged from 77 to 85% among the four study groups.

An accompanying editorial by Karlawish² highlights the novelty of this trial's design, . . . [Full Text of this Article]

Related Letters:

Retraction: Hussain HM, Hotopf M, Oyebode F. Atypical Antipsychotic Drugs and Alzheimer's Disease. N Engl J Med 2007;356:416.
Hussain H. M.
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N Engl J Med 2007; 356:1481, Apr 5, 2007. Correspondence

This article has been cited by other articles:

• Rosenheck, R. A., Leslie, D. L., Sindelar, J. L., Miller, E. A., Tariot, P. N., Dagerman, K. S., Davis, S. M., Lebowitz, B. D., Rabins, P., Hsiao, J. K., Lieberman, J. A., Schneider, L. S., for the Clinical Antipsychotic Trial of Interventi, (2007). Cost-Benefit Analysis of Second-Generation Antipsychotics and Placebo in a Randomized Trial of the Treatment of Psychosis and Aggression in Alzheimer Disease. Arch Gen Psychiatry 64: 1259-1268 [Abstract] [Full Text]  
• Hussain, H. M. (2007). Retraction: Hussain HM, Hotopf M, Oyebode F. Atypical Antipsychotic Drugs and Alzheimer's Disease. N Engl J Med 2007;356:416.. NEJM 356: 1481-1481 [Full Text]