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FOCUS ON RESEARCH Previous Volume 356:444-445 February 1, 2007 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Perspective Perspective by Scott, L. M. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Scott, L. M. PubMed Citation

Janus kinase 2 (JAK2) is a cytoplasmic tyrosine kinase that transduces signals, especially those triggered by hematopoietic growth factors such as erythropoietin, in normal and neoplastic cells. In March and April 2005, four groups of investigators reported finding an acquired JAK2 mutation (termed JAK2 V617F) in association with polycythemia vera and related myeloproliferative disorders.¹ These seminal reports have already been cited many times, and JAK2 is now a target for the development of new treatments for the myeloproliferative disorders. JAK2 V617F is detectable in more than 95% of patients who have polycythemia vera, as defined according to conventional criteria. The . . . [Full Text of this Article]

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Dr. Tefferi is a professor in the Department of Internal Medicine, Division of Hematology, Mayo Clinic College of Medicine, Rochester, MN.

This article has been cited by other articles:

• Vardiman, J. W. (2008). Integration of Histology and Genetics in the Diagnosis and Classification of Myeloproliferative Neoplasms. Am Soc Clin Oncol Ed Book 2008: 339-345 [Abstract] [Full Text]  
• Steensma, D. P. (2007). The spectrum of molecular aberrations in myelodysplastic syndromes: in the shadow of acute myeloid leukemia. haematol 92: 723-727 [Full Text]  
• Tefferi, A., Pardanani, A. (2007). Evaluation of 'Increased' Hemoglobin in the JAK2 Mutations Era: A Diagnostic Algorithm Based on Genetic Tests. Mayo Clin Proc. 82: 599-604 [Abstract] [Full Text]