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Previous Volume 356:518-520 February 1, 2007 Number 5 Next

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When the causative gene for Huntington's disease was identified in 1993, there was great anticipation and hope that key disease-causing mechanisms would be identified quickly and that rational neuroprotective treatments would soon follow. Fourteen years later, it is obvious we were wrong. Potential pathogenic mechanisms have proliferated, and their relative importance is unclear. Now, three recent studies^1,2,3 have identified a protein and a mechanism that link two of the leading hypotheses of pathogenesis: transcriptional dysregulation and mitochondrial impairment (Figure 1).

View larger version (38K):   Figure 1. A Link between Proposed Mechanisms of Huntington's Disease. Huntington's disease is associated with transcriptional dysregulation (owing to interference . . . [Full Text of this Article]

 

Source Information

From the Pittsburgh Institute for Neurodegenerative Diseases and the Department of Neurology, University of Pittsburgh.

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