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Volume 356:544-546 February 8, 2007 Number 6
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Thailand and the Compulsory Licensing of Efavirenz
Robert Steinbrook, M.D.

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Of the many medicines for human immunodeficiency virus (HIV) infection, efavirenz, a nonnucleoside reverse-transcriptase inhibitor that became available in the late 1990s, is one of the most important. For the initial treatment of adults, the combination of efavirenz and two nucleoside reverse-transcriptase inhibitors "has become a standard-of-care comparator in clinical trials," according to Hammer et al.1 Moreover, efavirenz is available in a fixed-dose combination tablet with the nucleoside analogues emtricitabine and tenofovir; this tablet is taken only once a day. Efavirenz can cause birth defects when taken during the first trimester of pregnancy, so its use is restricted in women . . . [Full Text of this Article]


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Dr. Steinbrook (rsteinbrook@attglobal.net) is a national correspondent for the Journal.


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