A majority of healthy persons have, in their normal B cells,the defining event of follicular lymphoma — a t(14;18)translocation that brings together BCL2 and the gene encodingthe immunoglobulin heavy chain (Figure 1). The expression ofBCL2 (which inhibits apoptosis) is consequently increased andcontributes to the transformation of the normal B cell intofollicular lymphoma. These events alone are not enough for completetransformation; additional processes are required. A recentreport by Roulland et al.1 describes one such process and indicatesthat the cells with t(14;18) in healthy persons are closer tofollicular lymphoma than . . . [Full Text of this Article]
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From the Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD.
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